The national NIH sponsored PROMISE study has been concluded

The national NIH-sponsored PROMISE study has been concluded after a lot of hard work by Dr. Pamela Douglas and the rest of her team at the Duke Clinical Research Institute, as well as a lot of hard work performed at numerous enrollment sites throughout the United States and Canada. The study results were published in the prestigious New England Journal of Medicine, and were also presented at this year’s American College of Cardiology’s annual scientific meeting in March 2015. Deborah is credited in the study findings as one of only 5 enrolling sites in New Jersey.

This large national trial that enrolled over 10,000 patients looked at anatomical coronary assessment with cardiac CT versus functional stress testing (this included exercise stress treadmill, stress echo and stress nuclear tests, as well as pharmacological stress echo and stress nuclear)as a diagnostic tool for patients presenting with symptoms suggestive of the presence of coronary artery disease. The conclusion of this study was that an initial strategy of cardiac CT as compared with functional stress testing did not improve clinical outcomes. There was no statistical difference in the primary end points of death, myocardial infarction (aka “heart attack”), other acute coronary syndromes or procedural complications between the anatomical CT arm and the functional stress testing arm.

Deborah’s research team included the hard work of the Institutional Review Board (IRB), Dr. Renee Bullock-Palmer, who was the principal investigator for our site, Dr. David Hsi (co-investigator), as well as research coordinators Susan Cush, RN and Linda Dewey, RN, MSN, CCRC. Dr. Bullock-Palmer notes, “Fortunately, both types of testing (Cardiac CT, as well as various forms of functional stress testing) to detect the presence of coronary artery disease are available at Deborah Heart and Lung Center, and with an individualized ‘patient centered’ approach to the practice of medicine, our physicians are able to order the test that is best suited (indicated) for their patients in the detection of coronary artery disease, without compromising the quality of care.”

Congratulations to the whole Research Department on Deborah’s inclusion in the New England Journal of Medicine! As with all complex studies, there are multiple layers of involvement across numerous disciplines, and it is very rewarding when medical research can move forward in synch. Congrats to the team!